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Abstract #1783

Ultra-Short Echo Time 31P 3D MRSI at 3T with Novel Rosette k-space Trajectory

Brian Matthew Bozymski1, Xin Shen2, Ali Caglar Özen3, Serhat Ilbey3, Albert Thomas4, Mark Chiew5, Ulrike Dydak1,6, and Uzay Emir1,2
1School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 3Department of Radiology, Medical Center, University of Freiburg, Freiburg, Germany, 4Department of Radiology, University of California, Los Angeles, CA, United States, 5Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 6Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States


Feasibility of a novel, rosette trajectory UTE (70 μs) 3D 31P MRSI sequence is tested at 3T in phantoms and in upper leg scan with healthy subject. Braino phantom, proton resolution phantom, and highly concentrated 31P phantom test demonstrated proper reconstruction and metabolite localization. In vivo calculations of acquired PCr and β-ATP signals showed competitive SNR across 20 voxels of interest. With further acceleration, the sequence may serve as a superior alternative to conventional weighted 3D MRSI, allowing for greater SNR or resolution in briefer times. Notably, this unprecedentedly short UTE 31P MRSI intrinsically avoids baseline and phasing issues.

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