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Abstract #1784

Insights to the diffusion MRI ‘crossing fiber problem’: Characterizing the micro-structure in an MRI voxel using synchrotron radiation imaging

Hans Martin Kjer1,2, Mariam Andersson2, Alexandra Pacureanu3, Vedrana Andersen Dahl1, Anders Bjorholm Dahl1, and Tim Bjørn Dyrby1,2
1Technical University of Denmark, Kgs. Lyngby, Denmark, 2Danish Research Centre for Magnetic Resonance, Hvidovre, Denmark, 3European Synchrotron and Radiation Facility, Grenoble, France


Complex fiber regions where multiple tracts and bundles intersect are challenging to study with diffusion weighted MRI (DWI), due to the anatomical variation and 3D complexity within the volume covered by the measure voxel. Using x-ray nano-holotomography (XNH) we have been able to obtain and analyze a volume from a complex fiber region and make a comparison against DWI measurements from the same location of the same ex-vivo monkey brain. We derive comparable micro-structural features in the form of orientation distributions and anisotropy measures and show strong connections between them.

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