Meeting Banner
Abstract #1797

Multi-voxel PRESS for fast and sensitive static MRS of hyperpolarized nuclei

Wolfgang Gottwald1, Luca Nagel1, Geoffrey J. Topping1, and Franz Schilling1
1Department of Nuclear Medicine, TUM School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany


A multi-voxel point resolved spectroscopy (MV-PRESS) sequence was developed for measuring hyperpolarized 13C-labelled compounds, on a 7T preclinical small animal scanner. MV-PRESS allows to excite selected imaging voxels within a 3D volume with high sensitivity (i.e. 90° excitation angle). This method was compared to both single-voxel PRESS of a thermal 1H phantom and CSI with a hyperpolarized [1-13C]pyruvate phantom. MV-PRESS was then used to detect both pyruvate and lactate in healthy mouse kidneys after hyperpolarized [1-13C]pyruvate injection, using 2x2x2 mm3 voxels for a total of 4 voxels.

This abstract and the presentation materials are available to members only; a login is required.

Join Here