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Abstract #1800

Improving the biocompatibility of parahydrogen hyperpolarized [1-13C]pyruvate

Francesca Reineri1, Oksana Bondar1, Carla Carrera2, Eleonora Cavallari1, Erika Cerutti1, Ginevra Di Matteo1, and Silvio Aime1
1Molecular Biotechnology, University of Torino, Torino, Italy, 2Institute of Biostructure and Bioimaging, Nation Research Council, Torino, Italy


ParaHydrogen Induced Polarization is a hyperpolarization method much less technically demanding and affordable than d-DNP. The Side Arm Hydrogenation method allowed to obtain hyperpolarized [1-13C]pyruvate that can be used for metabolic studies, but concerns about the safety and bio-compatibility of the final aqueous solution of the HP products may be present, due to organic solvents and metal complex. In this work, a method to remove all the traces of toxic solvents and metal complex from the final product will be presented, together with the 13C-MR images obtained using the metabolite thus hyperpolarized.

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