Meeting Banner
Abstract #1799

Multi-band echo-planar spectroscopic imaging of hyperpolarized 13C probes in a compact preclinical PET/MR scanner

Cornelius von Morze1, Tyler Blazey1, Richard Baeza2, Ruslan Garipov2, Timothy Whitehead1, Galen D Reed3, Joel R Garbow1, and Kooresh I Shoghi1
1Washington University, St Louis, MO, United States, 2MR Solutions, Guildford, United Kingdom, 3GE Healthcare, Dallas, TX, United States


Hyperpolarized (HP) 13C MRI requires advanced pulse sequences to capture the dynamic, localized metabolic information. We developed an echo planar spectroscopic imaging (EPSI) pulse sequence incorporating multi-band spectral-spatial radiofrequency (SSRF) pulses for rapid and efficient HP 13C MRI on a new cryogen-free simultaneous PET/MR molecular imaging platform with compact footprint. Excitation profiles were measured in phantoms, and the SSRF-EPSI sequence was tested in rats using two HP 13C probes. We also obtained simultaneous 18F-FDG-PET data for comparison. In conclusion, advanced 13C SSRF imaging approaches are feasible on the new PET/MR platform, facilitating direct comparison with PET.

This abstract and the presentation materials are available to members only; a login is required.

Join Here