Postmortem Multiple Sclerosis Brain Lesion Identification at Low Field
Sharada Balaji1, Adam Dvorak1, Irene M. Vavasour2,3, Megan E. Poorman4, Hanwen Liu1, Emil Ljungberg5,6, Steve Williams6, Sean Deoni7, Cornelia Laule1,2,3,8, David K.B. Li2, G.R. Wayne Moore3,8,9, Alex MacKay1,2, and Shannon H. Kolind1,2,3,9
1Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 2Radiology, University of British Columbia, Vancouver, BC, Canada, 3International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 4Hyperfine, Inc., Guilford, CT, United States, 5Medical Radiation Physics, Lund University, Lund, Sweden, 6Neuroimaging, King's College London, London, United Kingdom, 7MNCH D&T, Bill and Melinda Gates Foundation, Seattle, WA, United States, 8Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 9Medicine, University of British Columbia, Vancouver, BC, Canada
A single hemisphere of postmortem brain tissue from a subject with multiple sclerosis (MS) was scanned at high (Philips Elition 3T) and low (Hyperfine Swoop 64mT) field strength to determine whether lesions could be detected using a portable low field MRI system. T2-weighted scans were acquired at both field strengths with matching resolutions to assess the impact of low field. Comparisons with a high resolution 3T scan showed that of 17 visible lesions, 11 were seen on the lower resolution 3T and 10 were seen on the 64mT scan, demonstrating the feasibility of lesion detection at low field.
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