Abstract #1815

Postmortem Multiple Sclerosis Brain Lesion Identification at Low Field

Sharada Balaji¹, Adam Dvorak¹, Irene M. Vavasour^2,3, Megan E. Poorman⁴, Hanwen Liu¹, Emil Ljungberg^5,6, Steve Williams⁶, Sean Deoni⁷, Cornelia Laule^1,2,3,8, David K.B. Li², G.R. Wayne Moore^3,8,9, Alex MacKay^1,2, and Shannon H. Kolind^1,2,3,9

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²Radiology, University of British Columbia, Vancouver, BC, Canada, ³International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ⁴Hyperfine, Inc., Guilford, CT, United States, ⁵Medical Radiation Physics, Lund University, Lund, Sweden, ⁶Neuroimaging, King's College London, London, United Kingdom, ⁷MNCH D&T, Bill and Melinda Gates Foundation, Seattle, WA, United States, ⁸Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁹Medicine, University of British Columbia, Vancouver, BC, Canada

Synopsis

A single hemisphere of postmortem brain tissue from a subject with multiple sclerosis (MS) was scanned at high (Philips Elition 3T) and low (Hyperfine Swoop 64mT) field strength to determine whether lesions could be detected using a portable low field MRI system. T₂-weighted scans were acquired at both field strengths with matching resolutions to assess the impact of low field. Comparisons with a high resolution 3T scan showed that of 17 visible lesions, 11 were seen on the lower resolution 3T and 10 were seen on the 64mT scan, demonstrating the feasibility of lesion detection at low field.

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