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Abstract #1823

Remapping of functional connectivity with optogenetic locus coeruleus activation in rats

Nmachi Anumba1, Michael Kelberman2, Corrie Smith1, Wen Ju Pan1, G Perrin Clavijo1, David Weinshenker2, and Shella Keilholz1
1Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA, United States, 2Human Genetics, Emory University, Atlanta, GA, United States


High tonic (3-5 Hz) locus coeruleus (LC) activity drives anxiety-like behaviors and the stress response via its dense afferents and receptor distribution profile. Previous studies have utilized DREADD stimulation to understand the global effects of elevating LC activity, but lacked temporal and patterned control of stimulation. Here, we combined optogenetic stimulation of the LC (5 Hz) with functional magnetic resonance imaging to better understand global changes in functional connectivity as a result of high tonic LC activity. We found that LC stimulation at 5 Hz resulted in a shift toward increased connectivity in ChR2 injected animals compared to mCherry controls.

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