Identifying modulation of brain states by optogenetic stimulation of lateral hypothalamus
Kengo Takahashi1, Yi Chen1, Patricia Pais-Roldán2, and Xin Yu3
1High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2Institute of Neuroscience and Medicine (INM-4), Forschungszentrum Jülich, Jülich, Germany, 3Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States
The lateral hypothalamus (LH) plays an important role in regulating the brain state changes during sleep and arousal state fluctuation. Although the anatomical projections of LH have been well-investigated, the brain-wide functional map by LH stimulation under different brain states has not been characterized. Here, we applied fMRI to characterize the whole brain activation maps under different brain states during anesthesia in response to LH optogenetic stimulation. We demonstrate that the underlying brain state determines distinct functional mapping features upon LH activation.
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