Meeting Banner
Abstract #1827

Multimodal BOLD and CBV MRI for artifact correction in fluorescence recordings

Henriette Lambers1, Lydia Wachsmuth1, and Cornelius Faber1
1Clinic for Radiology, University Hospital Muenster, Muenster, Germany


Combining fMRI and fluorescence recordings has become an important tool for neuroimaging. However, hemodynamic changes lead to artifacts in fluorescence recordings, since blood absorbs fluorescence light. We investigated the hemodynamic artifact in functional and pharmacological MRI and fluorescence measurements and present an MRI-based correction method. In both stimulation and lactate injection experiments, hemodynamic artifacts in FRET recordings occurred. These artifacts cannot be removed effectively using a standard (purely optical) correction method. An MRI-based correction presented in this work eliminates the artifact while the expected fluorescence signal changes persist.

This abstract and the presentation materials are available to members only; a login is required.

Join Here