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Abstract #1828

fMRI in the Mouse Spinal Cord during peripheral somatosensory Stimulation

Amon Allelein1, Bruno Pradier1, Huifen Chen2, and Cornelius Faber2
1Radiology, UKM, Muenster, Germany, 2UKM, Muenster, Germany


The spinal cord is an important hub for the integration and processing of peripheral somatosensory stimuli within the central nervous system, however, mouse spinal cord functional imaging is not yet established. We successfully performed BOLD fMRI in the mouse spinal cord using 1 electric and 3 different mechanical stimulation modalities in one session. Graph theory-based network analyses showed strong positive correlations within the dorsal spinal cord laminae of L4 and L5. A negative correlation between the dorsal and ventral regions within the same segment suggests the presence of a vascular steal effect.

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