Intracortical microstimulation is one of the most common techniques used to activate cortical functional networks and probe causal connections. This study investigates whether BOLD signals can detect layer-specific functional circuit responses to electrical brain stimulation. We delivered electrical current to different layers of secondary somatosensory cortex (S2) and detected layer-specific BOLD activations. Effective functional connectivity analysis revealed different networks to different layers of S2 cortex.
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