Layer-specific microsimulation of S2 cortex revealed distinct functional microcircuits in non-human primate brain
Pai-Feng Yang1,2, Feng Wang1,2, Jamie L. Reed1,2, Zhangyan Yang1,2, John C. Gore1,2, and Li Min Chen1,2
1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 2Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States
Intracortical microstimulation is one of the most common techniques used to activate cortical functional networks and probe causal connections. This study investigates whether BOLD signals can detect layer-specific functional circuit responses to electrical brain stimulation. We delivered electrical current to different layers of secondary somatosensory cortex (S2) and detected layer-specific BOLD activations. Effective functional connectivity analysis revealed different networks to different layers of S2 cortex.
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