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Abstract #1884

Flow Effects on Spatial Spectral Excitation of Hyperpolarized Agents

Christopher Michael Walker1, Keith Michel1, Collin J Harlan1, Zhan Xu1, Gary Martinez1, Dawid Schellingerhout2, Stephen Y. Lai3, and James A. Bankson1
1Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, 2Neuroradiology Department, MD Anderson Cancer Center, Houston, TX, United States, 3Head & Neck Surgery, MD Anderson Cancer Center, Houston, TX, United States

Synopsis

Simulations were used to evaluate the effect of rapid vascular flow on spatial spectral pulses used for hyperpolarized MRI. Simulation results show that flow effects reduced the on-resonance excitation angle while increasing the off-resonance excitation in a velocity dependent manner. These excitation impacts will be particularly important when trying to estimate an arterial input function. Flow may also produce measurable lactate signal in flowing pyruvate, an effect that was observed in a hyperpolarized study of the thyroid.

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