Quantifying the exchange of hyperpolarized xenon gas between the airways, lung parenchyma, and red blood cells may provide valuable insights into the progression of lung graft failure, enabling earlier diagnosis of chronic lung allograft dysfunction (CLAD). By combining Xenon polarization Transfer Contrast (XTC) imaging with a multi-breath model of fractional ventilation, gas exchange efficiency was assessed in four lung transplant recipients 3-12 months post-surgery in order to identify baseline metrics and trends.
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