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Abstract #1885

Preliminary Assessment of Gas Exchange Efficiency in Lung Transplant Patients with Multi-breath Xenon Polarization Transfer Contrast Imaging

Faraz Amzajerdian1, Hooman Hamedani1, Ryan Baron1, Yi Xin1, Tahmina Achekzai1, Luis Loza1, Mostafa Ismail1, Ian Duncan1, Stephen Kadlecek1, Kai Ruppert1, and Rahim Rizi1
1University of Pennsylvania, Philadelphia, PA, United States


Quantifying the exchange of hyperpolarized xenon gas between the airways, lung parenchyma, and red blood cells may provide valuable insights into the progression of lung graft failure, enabling earlier diagnosis of chronic lung allograft dysfunction (CLAD). By combining Xenon polarization Transfer Contrast (XTC) imaging with a multi-breath model of fractional ventilation, gas exchange efficiency was assessed in four lung transplant recipients 3-12 months post-surgery in order to identify baseline metrics and trends.

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