This work illustrates current advancements in SABRE hyperpolarized pyruvate toward in vivo imaging, demonstrating that significant levels of polarization achieved on pyruvate enable dynamic spectroscopy and imaging of downstream chemical products. Specifically in this study we show the monitoring of chemical conversion of pyruvate to pyruvate hydrate using a pH change and pyruvate to CO2 by reaction with H2O2. While the current work only focuses on the study of the chemical conversion of hyperpolarized substrate in a phantom, these studies lay the groundwork for future in vivo injections that mirror these chemical conversion processes.
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