Advancing SABRE Toward In Vivo Imaging: Phantom Chemical Conversion of Hyperpolarized [1-13C]-Pyruvate
Patrick Michael TomHon1, Keilian MacCulloch1, David Orestes Guarin2, Erin Hardy2, Austin Browning1, Carlos Dedesma3, Matthew S Rosen2, Yi-Fen Yen2, and Thomas Theis4
1Chemistry, North Carolina State University, Raleigh, NC, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3Vizma Life Sciences, Chapel Hill, NC, United States, 4Chemistry, Physics, Biomedical Engineering, North Carolina State University, Raleigh, NC, United States
This work illustrates current advancements in SABRE hyperpolarized pyruvate toward in vivo imaging, demonstrating that significant levels of polarization achieved on pyruvate enable dynamic spectroscopy and imaging of downstream chemical products. Specifically in this study we show the monitoring of chemical conversion of pyruvate to pyruvate hydrate using a pH change and pyruvate to CO2 by reaction with H2O2. While the current work only focuses on the study of the chemical conversion of hyperpolarized substrate in a phantom, these studies lay the groundwork for future in vivo injections that mirror these chemical conversion processes.
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