Abstract #1887

Dynamic 1H MR spectroscopy of yeast metabolism during gamma irradiation using a 1.5T MR-Linac

Liam S. P. Lawrence^1,2, Viktor Iakovenko³, Wendy Oakden¹, Rachel W. Chan¹, Greg J. Stanisz^1,2,4, and Angus Z. Lau^1,2

¹Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ²Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Department of Medical Physics, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴Department of Neurosurgery and Paediatric Neurosurgery, Medical University, Lublin, Poland

Synopsis

1H MR spectroscopy (MRS) can detect metabolic changes in treated tumours that could indicate therapeutic response. MR response assessment might inform radiation dose plan adaptation on MRI linear accelerators (MR-Linacs). We report the first MRS experiments on a 1.5T MR-Linac. Dynamic spectra of yeast during fermentation were acquired with and without irradiation, to measure real-time changes in metabolism. Ethanol production was detectable. The Larmor frequency drifted by 33 Hz over 11 minutes during irradiation, degrading spectral quality. While no differences in ethanol production were detected between irradiation/control experiments, the phantom setup could be optimized to increase dose and improve repeatability.

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