1H MR spectroscopy (MRS) can detect metabolic changes in treated tumours that could indicate therapeutic response. MR response assessment might inform radiation dose plan adaptation on MRI linear accelerators (MR-Linacs). We report the first MRS experiments on a 1.5T MR-Linac. Dynamic spectra of yeast during fermentation were acquired with and without irradiation, to measure real-time changes in metabolism. Ethanol production was detectable. The Larmor frequency drifted by 33 Hz over 11 minutes during irradiation, degrading spectral quality. While no differences in ethanol production were detected between irradiation/control experiments, the phantom setup could be optimized to increase dose and improve repeatability.
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