Abstract #1894

Parahydrogen-Based Hyperpolarization of a Pyruvate Ester to 25% Within an MRI System Using SAMBADENA

Henri de Maissin^1,2, Vladislav Ivantaev¹, Christoph A. Müller^1,2, Obaid Mohiuddin¹, Jürgen Hennig³, Dominik von Elverfeldt³, Jan-Bernd Hövener⁴, Strefan Glöggler^5,6, and Andreas Benjamin Schmidt^1,2

¹Radiology - Medical Physics, University Medical Center Freiburg, Freiburg, Germany, ²German Cancer Consortium (DKTK) partner site Freiburg, German Cancer Center (DKFZ), Heidelberg, Germany, ³University Medical Center Freiburg, Freiburg, Germany, ⁴3Section Biomedical Imaging, Molecular Imaging North Competence Center (MOINCC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein and Kiel University, Kiel, Germany, ⁵Max Planck Institute for Biophysical Chemistry, Göttingen, Germany, ⁶Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany

Synopsis

Parahydrogen (pH₂) and Synthesis Amid the Magnet Bore Allow Dramatically Enhanced Nuclear Alignment (SAMBADENA) and have recently enabled hyperpolarization (HP) of ¹³C and subsequent in vivo administration of the produced contrast agent inside an MRI system. pH₂ Induced Polarization (PHIP) by Side-Arm Hydrogenation (PHIP-SAH) has extended the portfolio of PHIP agents to metabolically-active molecules such as acetate, lactate, and pyruvate, but typically requires hydrogenation in organic solvents like chloroform. Here we present our new, solvent-compatible SAMBADENA setup and preliminary results of the ¹³C HP in chloroform of the PHIP-SAH molecule cinnamyl-pyruvate – opening the pathway towards metabolic studies with SAMBADENA.

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