Parahydrogen-Based Hyperpolarization of a Pyruvate Ester to 25% Within an MRI System Using SAMBADENA
Henri de Maissin1,2, Vladislav Ivantaev1, Christoph A. Müller1,2, Obaid Mohiuddin1, Jürgen Hennig3, Dominik von Elverfeldt3, Jan-Bernd Hövener4, Strefan Glöggler5,6, and Andreas Benjamin Schmidt1,2
1Radiology - Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 2German Cancer Consortium (DKTK) partner site Freiburg, German Cancer Center (DKFZ), Heidelberg, Germany, 3University Medical Center Freiburg, Freiburg, Germany, 43Section Biomedical Imaging, Molecular Imaging North Competence Center (MOINCC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein and Kiel University, Kiel, Germany, 5Max Planck Institute for Biophysical Chemistry, Göttingen, Germany, 6Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany
Parahydrogen (pH2) and Synthesis Amid the Magnet Bore Allow Dramatically Enhanced Nuclear Alignment (SAMBADENA) and have recently enabled hyperpolarization (HP) of 13C and subsequent in vivo administration of the produced contrast agent inside an MRI system. pH2 Induced Polarization (PHIP) by Side-Arm Hydrogenation (PHIP-SAH) has extended the portfolio of PHIP agents to metabolically-active molecules such as acetate, lactate, and pyruvate, but typically requires hydrogenation in organic solvents like chloroform. Here we present our new, solvent-compatible SAMBADENA setup and preliminary results of the 13C HP in chloroform of the PHIP-SAH molecule cinnamyl-pyruvate – opening the pathway towards metabolic studies with SAMBADENA.
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