A comparison of human brain GABA levels measured at 3T and 7T
Tiffany Bell1,2,3, Dana Goerzen4, Masoumeh Dehghani4, Jamie Near4,5,6, and Ashley D Harris1,2,3
1Department of Radiology, University of Calgary, Calgary, AB, Canada, 2Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 3Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, 4Centre d’Imagerie Cerebrale, Douglas Mental Health Institute, Montreal, QC, Canada, 5Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 6Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada
Measuring GABA in the human brain in vivo using magnetic resonance spectroscopy (MRS) is not trivial due to its low abundance in the brain and the overlap of signal from higher concentration metabolites. At 3T, an editing sequence is typically used to isolate the GABA signal. Data acquired at 7T has higher SNR and better spectral resolution, therefore editing is often not used to measure GABA at this field strength. Here we compare GABA levels acquired at 7T using STEAM to GABA levels acquired at 3T using GABA-edited MEGA-PRESS and find little agreement between the two measures.
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