Abstract #1892

Investigating metabolite regional dependencies in the frontal lobe: overlapping small and large voxels

Marilena M DeMayo^1,2,3,4,5, Alexander McGirr^2,3,4, Ben Selby^3,6, Frank MacMaster⁷, Chantel T Debert^3,6, and Ashley D Harris^1,3,5

¹Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ²Department of Psychiatry, University of Calgary, Calgary, AB, Canada, ³Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ⁴Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada, ⁵Department of Radiology, University of Calgary, Calgary, AB, Canada, ⁶Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada, ⁷Provincial Addiction and Mental Health (PAMH) Portfolio, University of Calgary, Calgary, AB, Canada

Synopsis

Small anatomically specific voxels in cerebral cortex require a large number of averages to quantify metabolites by magnetic resonance spectroscopy. It is unclear whether cortical regional variability in metabolite concentration requires small voxels, or whether a larger voxel which incorporates the region of interest can provide adequately representative measures with fewer averages. Concentrations of glutamate, glx, creatine, choline, myo-inositol and N-acetyl-aspartate (NAA) were correlated within subjects between an overlapping small (15x15x15mm) and large (30x30x30mm) voxel. There was a significant correlation between creatine measures, while choline showed a positive trend. There was no correlation between glutamate, glx, NAA, and myo-inositol.

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