Abstract #1891

semi-LASER MRS at 3T with TR=5s: All the Signal, Similar Scan Time, and Minimal T1 Weighting

Alex Ensworth^1,2, Laura R. Barlow^3,4, Piotr Kozlowski^1,2,3,4, Erin L. MacMillan^3,4,5, and Cornelia Laule^1,2,3,6

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada, ³Radiology, University of British Columbia, Vancouver, BC, Canada, ⁴UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ⁵Philips Canada, Mississauga, ON, Canada, ⁶Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

Synopsis

The choice of repetition time (TR) in MR spectroscopy studies is widely debated. A shorter TR results in more clinically acceptable scan times, however due to T1 effects, the metabolite concentrations are reduced. We used semi-LASER MRS to compare the SNR and absolute metabolite concentrations for TR=2,5 and 8s. We demonstrate it is possible to achieve similar SNR and scan time using a TR of 5s with half the acquisitions compared to a TR of 2s, where the metabolite concentrations are 20% lower. Using a TR of 5s for any MRS study is feasible and recommended to minimize T1 effects.

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