Abstract #1910

Longitudinal decrement of cerebral blood flow in high-impact sports

Mahta Karimpoor¹, Moss Zhao¹, Brian Mills¹, Marios Georgiadis¹, Dean Tran¹, Maged Goubran², Nicole Mouchawar¹, Sohrab Sami³, Max Wintermark¹, Gerald Grant⁴, David Camarillo⁵, Greg Zaharchuk¹, and Michael Zeineh¹

¹Radiology, Stanford University, Stanford, CA, United States, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Stanford Center for Clinical Research, Stanford, CA, United States, ⁴Neurosurgery, Stanford University, Stanford, CA, United States, ⁵Bioengineering, Stanford University, Stanford, CA, United States

Synopsis

Longitudinal changes (over four years) of cerebral blood flow (CBF) using arterial spin labeling MRI were investigated in a population of high-contact sport football college athletes and were compared to low-contact cohort of volleyball athletes. A linear-mixed-effects model was applied to assess CBF (normalized to the cerebellum) by sport (football vs. volleyball), time from baseline MRI, and the interaction between sport and time. Longitudinal analysis showed a prospective decline in perfusion in football compared to volleyball. Fourteen football players experienced an in-study concussion; in contrast to the longitudinal findings, football players exhibited acutely a mild increase in occipital lobe CBF.

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