Imaging grey and white matter microstructure simultaneously on a clinical scanner is now possible
Simona Schiavi1, Marco Palombo2,3,4, Domenico Zacà5, Francesco Tazza1, Caterina Lapucci6, Lucio Castellan7, Mauro Costagli1, and Matilde Inglese1,8
1Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy, 2Centre for Medical Image Computing (CMIC), Department of Computer Science, University College London, London, United Kingdom, 3Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 4School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom, 5Siemens Healthcare s.r.l, Milan, Italy, Milan, Italy, 6HNSR, IRRCS Ospedale Policlinico San Martino, Genoa, Italy, 7Department of Neuroradiology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, 8IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Diffusion MRI is a powerful technique that, thanks to advanced signal modelling like the Soma And Neurite Density Image (SANDI) can probe microstrucutral information of both grey and white matter. However, this model requires multishell acquisitions including b-values that are at least 6 times higher than those used in clinical practice. Here we propose a 10-minute acquisition protocol that enables to acquire such images on a clinical 3T scanner. We show the reproducibility of our approach on five healthy subjects as well as potential clinical impact on two subjects affected by multiple sclerosis.
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