Abstract #1911

Imaging grey and white matter microstructure simultaneously on a clinical scanner is now possible

Simona Schiavi¹, Marco Palombo^2,3,4, Domenico Zacà⁵, Francesco Tazza¹, Caterina Lapucci⁶, Lucio Castellan⁷, Mauro Costagli¹, and Matilde Inglese^1,8

¹Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy, ²Centre for Medical Image Computing (CMIC), Department of Computer Science, University College London, London, United Kingdom, ³Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, ⁴School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom, ⁵Siemens Healthcare s.r.l, Milan, Italy, Milan, Italy, ⁶HNSR, IRRCS Ospedale Policlinico San Martino, Genoa, Italy, ⁷Department of Neuroradiology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, ⁸IRCCS Ospedale Policlinico San Martino, Genoa, Italy

Synopsis

Diffusion MRI is a powerful technique that, thanks to advanced signal modelling like the Soma And Neurite Density Image (SANDI) can probe microstrucutral information of both grey and white matter. However, this model requires multishell acquisitions including b-values that are at least 6 times higher than those used in clinical practice. Here we propose a 10-minute acquisition protocol that enables to acquire such images on a clinical 3T scanner. We show the reproducibility of our approach on five healthy subjects as well as potential clinical impact on two subjects affected by multiple sclerosis.

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