Reliability and test-retest reproducibility of simple and advanced diffusion metrics were evaluated in healthy older adults. Advanced models such as Diffusion Kurtosis Imaging, White Matter Tract Integrity, Neurite Orientation Dispersion and Density Imaging and other multi-compartment methods have greater specificity but lower reliability and reproducibility than simple models such as DTI and spherical harmonic metrics. All models nevertheless had good or acceptable reproducibilty and reliability in certain cases. Particular care may be given when planning clinical research applications with advanced metrics, as greater sample sizes and/or improved data quality may be needed.
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