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Abstract #1917

Reliability and test-retest reproducibility of advanced diffusion metrics in healthy older adults

Rachel L. C. Barrett1, Robert Dallyn1, Marie-Stephanie Cahart1, Richard Stones2, Maarten Timmers3, Steven Williams1, and Flavio Dell'Acqua2
1Department of Neuroimaging, King's College London, London, United Kingdom, 2Department of Forensics and Neurodevelopmental Sciences, King's College London, London, United Kingdom, 3Janssen Research and Development, Janssen Pharmaceutica NV, Beerse, Belgium


Reliability and test-retest reproducibility of simple and advanced diffusion metrics were evaluated in healthy older adults. Advanced models such as Diffusion Kurtosis Imaging, White Matter Tract Integrity, Neurite Orientation Dispersion and Density Imaging and other multi-compartment methods have greater specificity but lower reliability and reproducibility than simple models such as DTI and spherical harmonic metrics. All models nevertheless had good or acceptable reproducibilty and reliability in certain cases. Particular care may be given when planning clinical research applications with advanced metrics, as greater sample sizes and/or improved data quality may be needed.

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