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Abstract #1923

7T metabolic MRI in focal epilepsy

Sarah M Jacobs1, Zahra Shams1, Evita C Wiegers1, Jannie P Wijnen1, Dennis W Klomp1, Edwin Versteeg1, Jeroen C.W. Siero1,2, Angelika Mühlebner3,4, Wim Van Hecke3, Pieter van Eijsden5, Pierre A Robe5, Maeike Zijlmans5,6, and Anja G van der Kolk1,7
1Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, Netherlands, 2Spinoza Centre for Neuroimaging Amsterdam, Amsterdam, Netherlands, 3Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands, 4Department of Pathology, Amsterdam University Medical Center, location AMC, Amsterdam, Netherlands, 5UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands, 6Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands, 7Department of Radiology, Radboud University Medical Center, Nijmegen, Netherlands


In this clinical study, we combined different (metabolic) MRI sequences at 7T to characterize focal epileptogenic lesions, and uncover potential metabolic markers that could help identifying the culprit lesion in MRI-negative epilepsy patients. Using QSM, we observed increased iron deposition in the affected hippocampus of two HS patients that was not found in the contralateral hippocampus, neither in a suspected HS patient with no abnormal tissue, nor in matched healthy volunteers. No increased iron deposition was found in patients with FCD or matched healthy volunteers. No significantly different metabolite ratios between patients and healthy volunteers were found using SV 1H-MRS.

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