Abstract #1923

7T metabolic MRI in focal epilepsy

Sarah M Jacobs¹, Zahra Shams¹, Evita C Wiegers¹, Jannie P Wijnen¹, Dennis W Klomp¹, Edwin Versteeg¹, Jeroen C.W. Siero^1,2, Angelika Mühlebner^3,4, Wim Van Hecke³, Pieter van Eijsden⁵, Pierre A Robe⁵, Maeike Zijlmans^5,6, and Anja G van der Kolk^1,7

¹Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, Netherlands, ²Spinoza Centre for Neuroimaging Amsterdam, Amsterdam, Netherlands, ³Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Department of Pathology, Amsterdam University Medical Center, location AMC, Amsterdam, Netherlands, ⁵UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands, ⁷Department of Radiology, Radboud University Medical Center, Nijmegen, Netherlands

Synopsis

In this clinical study, we combined different (metabolic) MRI sequences at 7T to characterize focal epileptogenic lesions, and uncover potential metabolic markers that could help identifying the culprit lesion in MRI-negative epilepsy patients. Using QSM, we observed increased iron deposition in the affected hippocampus of two HS patients that was not found in the contralateral hippocampus, neither in a suspected HS patient with no abnormal tissue, nor in matched healthy volunteers. No increased iron deposition was found in patients with FCD or matched healthy volunteers. No significantly different metabolite ratios between patients and healthy volunteers were found using SV ¹H-MRS.

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