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Abstract #1925

Microstructural Reorganizations in Thalamic Nuclei Across Characteristics of Temporal Lobe Epilepsy

KiChang Kang1, Anish V. Sathe1, Isaiah Ailes1, India Shelley1, Mashaal Syed1, Christopher Miller1, Feroze Mohamed1, Ashwini Sharan1, and Mahdi Alizadeh1
1Thomas Jefferson University, Philadelphia, PA, United States


Temporal lobe epilepsy (TLE) is the most common form of epilepsy which can become medically refractory and referred for surgery. The thalamus has been shown to demonstrate both structural and functional changes in TLE. However, little is known about microstructural alterations within individual thalamic nuclei. In this study, we used diffusion tensor imaging (DTI) to determine if subjects with unilateral TLE demonstrate hemispheric and intra-hemispheric differences in thalamic nuclei across clinical characteristics. We report statistically significant differences in nuclei in subjects with tonic-clonic seizures and mesial temporal sclerosis in both hemispheric and intra-hemispheric comparisons.

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