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Abstract #1926

Segmentation and Quantification of Venous structures and Perivascular Spaces in the Thalamus in Epilepsy Patients at 7T

Mackenzie Langan1,2, Gaurav Verma1, Derek Smith1, Bradley Delman3, Madeline Fields4, Rebecca Feldman*1,5, and Priti Balchandani*1
1Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Icahn School of Medicine, Graduate School of Biomedical Sciences, New York, NY, United States, 3Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Department of Neurology, Mount Sinai Hospital, New York, NY, United States, 5Department of Computer Science, Math, Physics, and Statistics, University of British Columbia, Vancouver, BC, Canada


Here we outline a preliminary analysis using a novel method which leverages UHF neuroimaging to measure detectable differences in vasculature within the thalamus that may not be detectable at lower field strengths. We provide a tool for detection and quanitifcation of vessels, perivascular spaces, and subsequent overlaps within the thalamus which may be relevant to uncover possible underlying neuroinflammatory processes in focal epilepsy patients. In our analysis, we found a significant difference in the number of thalamic vessels in patients compared to controls, providing a possible marker to measure abnormal or disordered vessel growth possibly associated with increased seizure activity.

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