Abstract #1927

Network efficiency of structural covariance networks relate to cognitive performance in children with childhood absence epilepsy

Merel JA Eussen^1,2, Jacobus FA Jansen^2,3, Twan Voncken⁴, Mariette HJA Debeij-van Hall⁵, Jos GM Hendriksen^4,5, Jeroen R Vermeulen⁴, Sylvia Klinkenberg⁴, Walter H Backes^2,3, and Gerhard Drenthen^2,3

¹Department of Biomedical Technology, Eindhoven University of Technology, Eindhoven, Netherlands, ²Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ³School for Mental Health & Neuroscience, Maastricht University, Maastricht, Netherlands, ⁴Department of Neurology, Maastricht University Medical Center, Maastricht, Netherlands, ⁵Department of Behavioral Sciences, Kempenhaeghe, Heeze, Netherlands

Synopsis

Cognitive deficits have been reported in children with childhood absence epilepsy (CAE). Regional alterations in morphology in children with CAE are likely related to the changes in the underlying network structure. Structural covariance networks (SCNs) based on interregional correlations of cortical thicknesses can describe these changes. To relate cognitive performance to network efficiency, individual SCNs are derived from anatomical MR images of the control group and one patient. The global efficiency calculated from the resulting SCNs showed a negative relation with cognitive performance for children with CAE.

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