Abstract #1928
Structural Connectivity in Default Mode Network May Lateralize Temporal Lobe Epilepsy: A Graph-Theory Approach
Fatemeh Salimi 1, Saeed Masoudnia 2, Alireza Fallahi 2,3, Narges Hoseini Tabatabaei4, Mohammadreza Ay1,2, and Mohammad-Reza Nazem-Zadeh1,2
1Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 2Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 3Biomedical Engineering, Hamedan University of Technology, Hamedan, Iran (Islamic Republic of), 4Medical School, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of)
Synopsis
Difficulties in lateralizing the epileptogenic side of the brain challenge the temporal lobe epilepsy (TLE) surgery. We examined structural connectivity in default mode network (DMN) based on graph network analysis for specifying the epileptogenic side of the brain in TLE patients. The results showed significantly different connectivity in DMN nodes among the TLE patients compared to the control cohort. DMN regions with abnormal structural connectivity in TLE subjects corresponded with the epileptogenic brain sides.
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