Abstract #1929

White matter microstructure characterisation in hippocampal sclerosis and cryptogenic temporal lobe epilepsy

Nicolò Rolandi¹, Fulvia Palesi¹, Francesco Padelli², Isabella Giachetti², Domenico Aquino², Paul Summers³, Elena Tartara⁴, Giancarlo Germani³, Valeria Mariani⁵, Egidio D'Angelo^1,6, Laura Tassi⁵, Claudia Angela Michela Gandini Wheeler-Kingshott^1,6,7, and Paolo Vitali^3,8

¹Department of Brain and Behavioral Science, University of Pavia, Pavia, Italy, ²Neuroradiology, I.R.C.C.S. Istituto Neurologico Carlo Besta, Milano, Italy, ³Neuroradiology, IRCCS Mondino Foundation, Pavia, Italy, ⁴Epilepsy Centre, IRCCS Mondino Foundation, Pavia, Italy, ⁵“C. Munari” Epilepsy Surgery Centre, ASST Niguarda, Milano, Italy, ⁶Brain Connectivity Center Research Unit, IRCCS Mondino Foundation, Pavia, Italy, ⁷NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, UCL Queen Square Institute of Neurology, London, United Kingdom, ⁸Radiology, IRCCS Policlinico San Donato, San Donato Milanese, Italy

Synopsis

Temporal lobe epilepsy is characterised by heterogeneous aetiology. In this work we focused on hippocampal sclerosis and cryptogenic groups. In order to characterize microstructure white matter alterations underlying the pathology, we performed a regional analysis of the temporal lobe white matter. Our results showed less disruptive microstructural changes in cryptogenic patients. Alterations in Axial Diffusivity and Neurite Density Index in hippocampal sclerosis potentially indicate significant axonal degeneration. Further investigations are needed to ascertain the value of Orientation Dispersion Index as a possible biomarker to predict surgery outcome.

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