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Abstract #1929

White matter microstructure characterisation in hippocampal sclerosis and cryptogenic temporal lobe epilepsy

Nicolò Rolandi1, Fulvia Palesi1, Francesco Padelli2, Isabella Giachetti2, Domenico Aquino2, Paul Summers3, Elena Tartara4, Giancarlo Germani3, Valeria Mariani5, Egidio D'Angelo1,6, Laura Tassi5, Claudia Angela Michela Gandini Wheeler-Kingshott1,6,7, and Paolo Vitali3,8
1Department of Brain and Behavioral Science, University of Pavia, Pavia, Italy, 2Neuroradiology, I.R.C.C.S. Istituto Neurologico Carlo Besta, Milano, Italy, 3Neuroradiology, IRCCS Mondino Foundation, Pavia, Italy, 4Epilepsy Centre, IRCCS Mondino Foundation, Pavia, Italy, 5“C. Munari” Epilepsy Surgery Centre, ASST Niguarda, Milano, Italy, 6Brain Connectivity Center Research Unit, IRCCS Mondino Foundation, Pavia, Italy, 7NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, UCL Queen Square Institute of Neurology, London, United Kingdom, 8Radiology, IRCCS Policlinico San Donato, San Donato Milanese, Italy


Temporal lobe epilepsy is characterised by heterogeneous aetiology. In this work we focused on hippocampal sclerosis and cryptogenic groups. In order to characterize microstructure white matter alterations underlying the pathology, we performed a regional analysis of the temporal lobe white matter. Our results showed less disruptive microstructural changes in cryptogenic patients. Alterations in Axial Diffusivity and Neurite Density Index in hippocampal sclerosis potentially indicate significant axonal degeneration. Further investigations are needed to ascertain the value of Orientation Dispersion Index as a possible biomarker to predict surgery outcome.

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