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Abstract #1932

Static and Dynamic Resting-State fMRI Features to Localize Brain Areas Generating Epileptic Spikes

Siu Lung Tang1, Kristina Sabaroedin2, Will Wilson2, Daniel Pittman2, Paolo Federico2, and Pierre LeVan2
1Department of Pediatrics, University of Calgary, Calgary, AB, Canada, 2Department of Radiology, University of Calgary, Calgary, AB, Canada


The potential of using features derived from resting-state fMRI time series to localize epileptic brain areas was studied. Static and dynamic correlations between local spike rates measured with intracranial EEG and regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and functional connectivity (FC), respectively, were analyzed based on data collected from 13 subjects with refractory epilepsy. While static measures of ReHo and ALFF were not statistically correlated with spike rates measured during long-term monitoring, static correlation with FC was apparent. However, in dynamic analysis, temporal variations in instantaneous spike rates were associated with synchronous fluctuations of both ALFF and FC.

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