fMRI Can Detect Functional Connections of Seizure Spread Regions to Onset Zones in Patients with Mesial Temporal Sclerosis
Anish Vinay Sathe1, Michael Kogan2, KiChang Kang1, Jingya Miao1, Mashaal Syed1, Isaiah Ailes1, Caio Matias1, Feroze Mohamed1, Ashwini Sharan1, and Mahdi Alizadeh1
1Thomas Jefferson University, Philadelphia, PA, United States, 2The University of New Mexico, Albuquerque, NM, United States
Epilepsy is a disease involving seizure initiation and often spread. sEEG has shown that areas of seizure spread are correlated with onset regions. We find that seed-to-voxel analysis via amplitude synchronization of fMRIs of epilepsy patients can also detect significant correlations between seizure onset and spread zones. These results validate fMRI analysis as a promising noninvasive method to detect other correlated brain regions that may be involved in seizure propagation.
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