Abstract #1931

fMRI Can Detect Functional Connections of Seizure Spread Regions to Onset Zones in Patients with Mesial Temporal Sclerosis

Anish Vinay Sathe¹, Michael Kogan², KiChang Kang¹, Jingya Miao¹, Mashaal Syed¹, Isaiah Ailes¹, Caio Matias¹, Feroze Mohamed¹, Ashwini Sharan¹, and Mahdi Alizadeh¹

¹Thomas Jefferson University, Philadelphia, PA, United States, ²The University of New Mexico, Albuquerque, NM, United States

Synopsis

Epilepsy is a disease involving seizure initiation and often spread. sEEG has shown that areas of seizure spread are correlated with onset regions. We find that seed-to-voxel analysis via amplitude synchronization of fMRIs of epilepsy patients can also detect significant correlations between seizure onset and spread zones. These results validate fMRI analysis as a promising noninvasive method to detect other correlated brain regions that may be involved in seizure propagation.

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