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Abstract #1937

SENSE and Compressed SENSE chemical shift encoded multi-gradient echo for T2* quantification in the liver

Elisabeth Sarah Pickles1,2, John Connell2, Stella Nay Kyi Kin2, Alison Telford2, Arina Kazimianec2, Michael Brady2, Daniel Bulte1, Oi Fong Chong3, Han Jun Choo4, Sulaiha Binte Ithnin5, Jason Pik Eu Chang6, Guan Huei Lee7, Marianne Anastasia De Roza8, Kok Kiong Ong9, Sabrina Yi-Mei Wee10, Kee Tung Tan11, Ngiap Chuan Tan12, Han Chong Toh13, Yu Jun Wong14,15, Wei Lyn Yang16, Xin Yi Yeap17, Cheryl Min En Chua18, Jacelyn Siou Sze Chua18, Jade Shu Qi Goh18, Lynette Soh Han Lai18, Yu Ki Sim18, and Pierce K.H. Chow19,20
1Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 2Perspectum Ltd, Oxford, United Kingdom, 3SingHealth Polyclinic - Bedok, Singapore, Singapore, 4SingHealth Polyclinic - Sengkang, Singapore, Singapore, 5SingHealth Polyclinic - Tampines, Singapore, Singapore, 6Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore, 7Division of Gastroenterology and Hepatology, National University Hospital, Singapore, Singapore, 8Department of Gastroenterology and Hepatology, Sengkang General Hospital, Singapore, Singapore, 9SingHealth Polyclinic - Outram, Singapore, Singapore, 10SingHealth Polyclinic - Bukit Merah, Singapore, Singapore, 11SingHealth Polyclinic - Marine Parade, Singapore, Singapore, 12SingHealth Polyclinic - Pasir Ris, Singapore, Singapore, 13Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore, 14Department of Gastroenterology & Hepatology, Changi General Hospital, Singapore, Singapore, 15Duke-NUS Medical School, Singapore, Singapore, 16Gastroenterology and Hepatology, Tan Tock Seng Hospital, Singapore, Singapore, 17SingHealth Polyclinic - Punggol, Singapore, Singapore, 18Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore, 19Department of Hepato-pancreato-biliary and Transplant Surgery, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore, 20Surgery Academic Clinical Programme, Duke-NUS Medical School, Singapore, Singapore


T2*, measured using 3D breath-hold chemical shift encoded multi-gradient echo can be used to estimate liver iron concentration. The breath-hold duration (typically 10-20 s) with traditional parallel imaging acceleration techniques such as Sensitivity Encoding (SENSE) can be difficult for patients. Compressed SENSE (C-SENSE) can be used to decrease acquisition time. We compare T2* obtained with SENSE and C-SENSE in 21 patients. We found that C-SENSE acquisition was faster (9 s vs 18 s), with strong correlation and agreement with SENSE. Our findings suggest C-SENSE may potentially improve patient tolerance and turnover speed for T2* acquisitions when compared to SENSE.

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