This work aimed at texture analysis based on mean apparent diffusion coefficient (MD) of diffusion kurtosis imaging (DKI) to evaluate the treatment efficacy of transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC). The results showed that MD texture features can differentiate objective response and non-response groups. When using the single parameter, the GreyLevelNonuniformity_angle135_offset1 achieved the best result (AUC: 0.714, sensitivity: 68.2%, specificity: 81%). In the combined diagnosis of multiple parameters, FrequencySize,MaxIntensity, GreyLevelNonuniformity_angle0_offset1 and GreyLevelNonuniformity_angle135_offset1 were combined to obtain the best combined diagnosis（AUC：0.760，sensitivity: 81.8%, specificity: 66.7%).
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