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Abstract #1940

MRI Correlation with Liver Explant Pathology: LIRADS Treatment Response Algorithm for Residual HCC After Y-90 Therapy

Matthew Harwood1, Parth Parikh2, Alexander Clinkenbeard1, Sailen Naidu3, Marcela Salomao4, and Alvin Silva1
1Radiology, Mayo Clinic Arizona, Phoenix, AZ, United States, 2Mayo Clinic Alix School of Medicine, Arizona, Scottsdale, AZ, United States, 3Interventional Radiology, Mayo Clinic Arizona, Phoenix, AZ, United States, 4Pathology, Mayo Clinic Arizona, Phoenix, AZ, United States


The liver imaging and reporting data system treatment response algorithm (LIRADS TRA) for CT and MRI has been used to predict residual viable tumor after treatment with yttrium-90 (Y-90). This single-center cohort of 20 patients were reviewed using the LIRADS TRA assessing residual viable tumor following Y-90 therapy. Pathology of subsequent liver explants was the reference standard. The LIRADS TRA predicted positive treatment effect (nonviable): NPV 82.4% (95% CI 0.47-1.55), accuracy 75% (72.0-89.4). The results of this preliminary study will need further validation in a larger, similar, pathologic-confirmed cohort.

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