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Abstract #1943

Scyllo-inositol: concentration changes associated with aging and alcohol use, and T2 measurement.

Dinesh K Deelchand1, J. Riley McCarten2,3, Laura Hemmy2,4, Edward Auerbach1, Lynn Eberly5, and Małgorzata Marjańska1
1Radiology, University of Minnesota, Minneapolis, MN, United States, 2Geriatric Research, Veterans Affairs Health Care System, Minneapolis, MN, United States, 3Department of Neurology, University of Minnesota, Minneapolis, MN, United States, 4University of Minnesota, Minneapolis, MN, United States, 5Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States

Synopsis

The goals of this study were to investigate the effect of alcohol usage on scyllo-inositol (sIns) in young and older healthy adults, and measure the T2 of sIns in young and older healthy adults. Two brain regions (occipital cortex (OCC), posterior cingulate cortex (PCC)) were studied at 3T. sIns was measured using a short-echo-time STEAM while T2 was measured using LASER. sIns in OCC and PCC regions was found to increase as the brain ages; alcohol usage (0-2 drinks/week) was significantly different between age groups. In addition, there seems to be a trend towards lower T2 of sIns with age.

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