Sex-specific differences in the relationships between obesity, cerebral perfusion and grey matter volume
Brittany Intzandt1,2,3,4, Safa Sanami2,4,5, Julia Huck4,5, Rick D Hoge6, PREVENT-AD Research Group7, Louis Bherer 2,3,8, and Claudine J Gauthier2,4,5
1School of Graduate Studies, Concordia University, Montreal, QC, Canada, 2Centre EPIC, Montreal Heart Institute, Montreal, QC, Canada, 3Centre de Recherche de l’Institut Universitaire de Geriatrie de Montreal, Montreal, QC, Canada, 4PERFORM Centre, Concordia University, Montreal, QC, Canada, 5Department of Physics, Concordia University, Montreal, QC, Canada, 6Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 7StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montreal, QC, Canada, 8Department of Medicine, University of Montreal, Montreal, QC, Canada
Cerebral health declines in aging. Obesity is reported to accentuate, reduce or have no effect on these declines. Given sex differences are present for cerebral health and obesity individually, it is hypothesized these discrepancies are influenced by sex. Here, we investigated the relationship between obesity, cerebral structure and perfusion in aging females and males separately. Females revealed greater obesity was associated with increased structure and perfusion. Males demonstrated a positive relationship with obesity and perfusion, however, an inverse association was identified between structure and obesity. Future work should investigate the influence of other lifestyle factors on these sex-specific relationships
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