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Abstract #1945

Age-related changes to perivascular and parenchymal fluid flow dynamics with multi-compartment diffusion MRI

Kirsten Mary Lynch1, Rachel Custer1, Ryan P Cabeen1, Francesca Sibilia1, Arthur W Toga1, and Jeiran Choupan1
1USC Mark and Mary Stevens Institute for Neuroimaging and Informatics, University of Southern California, Los Angeles, CA, United States


Perivascular spaces (PVS) play a critical role in fluid transfer and waste clearance in the brain. PVS enlargement is associated with advancing age; however, the functional correlates of these changes are not well understood. Using multi-compartment diffusion models, we assessed the diffusion properties within the PVS and the surrounding parenchyma in a healthy aging cohort. We found age was significantly associated with increased perivascular free water content and reduced parenchymal free water content. These findings provide preliminary evidence of age-related changes to perivascular fluid transfer that may be indicative of waste clearance functional alterations.

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