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Abstract #1946

The primate corpus callosum - Age-related differences in morphology and microstructure

Rakshit Dadarwal1,2, Judith Mylius1, Amir Moussavi1, and Susann Boretius1,2
1Functional Imaging Laboratory, German Primate Center, Göttingen, Germany, 2Georg-August-University Göttingen, Göttingen, Germany


Aging of the brain has been associated with several structural and functional changes, including tissue volume loss, white matter integrity loss, and changes in iron concentration. However, the fundamental mechanism driving these changes and their significance in the development of age-related neurodegenerative diseases are still not very well understood. Due to their unequivocal similarity with humans, non-human primates may be of particular value to further explore these mechanisms. In this study, we looked at age-related morphological, tissue microstructural, and iron-concentration changes in the corpus callosum of macaques and marmosets.

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