Early diagnosis is crucial for the prognosis of patients with breast cancer. Postmenopausal women with oestrogen receptor positive cancer account for over half of all new diagnosis, with an imbalance of lipid composition in peri-tumoural adipose tissue. Since oestrogen is primarily modulated by mammary adipocytes, lipid composition monitoring for early sign of heterogeneous lipid deregulation is central to the accurate early detection. Novel chemical shift-encoded imaging (CSEI) allows rapid lipid mapping of whole breast. We set out to elucidate the spatial distribution in the deregulation of peri-tumoural lipid composition in postmenopausal patients with oestrogen receptor positive breast cancer using CSEI.
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