In vivo microstructure imaging based on diffusion weighted imaging can provide valuable information on tumor characteristics and response to cancer therapy. An oscillating diffusion gradient spin-echo sequence was used to acquire DW images with short diffusion times, along with those acquired by a pulsed diffusion gradient spin-echo sequence. Using a random walk with barriers model, microstructure/diffusion parameters in primary and nodal head and neck tumors were estimated prior to, and after two weeks of cancer treatment. Results show feasibility of this method to detect significant changes in these parameters, across the two imaging time points.
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