Sustainable products are becoming an integral part of our daily lives - in this study, we biosynthetically produced an MRI contrast agent from E.coli with an r1 of 6.0 (per-gadolinium, 7T field strength, room temperature) that provides the user with optical feedback through a jump in green fluorescence upon binding free gadolinium in solution. We anticipate this will reduce the amount of resources spent on quality control (in assessing the amount of unchelated gadolinium that could otherwise introduce toxicity), whereas its compatibility with lyophilization is expected to improve storage conditions in terms of longevity, stability, and transportation costs.
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