Abstract #1989

3D Bioprinted MRI-Trackable Regenerative Scaffold for Post-Implantation Monitoring

Sadi Loai^1,2, Daniel A. Szulc^1,2, and Hai-Ling Margaret Cheng^1,2,3

¹Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada, ²Translational Biology & Engineering Program, Ted Rogers Centre for Heart Research, Toronto, ON, Canada, ³The Edward S. Rogers Sr. Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada

Synopsis

3D bioprinted scaffolds are one of the most novel and promising tissue regenerative therapeutics currently in development (e.g. to repair damaged cardiac tissue). Validation of correct scaffold placement and retention post-implantation is essential, but it is challenging to visualize scaffolds in-vivo given their similar material properties to native tissue. In this study, a T1-reducing contrast agent, MnPNH₂, was utilized to create an MR-trackable, bioprinted scaffold. In-vitro and in-vivo results confirmed the novel scaffold provided an environment conducive to cell growth and offered significant bright contrast for post-implantation scaffold monitoring in rats.

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