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Abstract #1990

A Novel Manganese EOB-Pyclen Diacetate Chelate for Liver-Specific MRI

Ryan Hall1, Jing-Can Qin1, Victoria Laney1, and Nadia Ayat1
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States


MRI is increasingly utilized for the diagnosis of liver disease and focal liver lesions. While liver-targeted gadolinium-based contrast agents (GBCAs) have high efficacy, they are shadowed by safety concerns regarding tissue retention. We have developed a liver-targeted manganese alternative – Mn-EOB-PC2A – that uses a liver-targeted ethoxybenzyl modified macrocyclic pyclen diacetate platform. Relaxivity measurements for Mn-EOB-PC2A suggest comparable performance to the GBCA alternatives, and in vitro characterization suggests strong uptake in hepatocytes with minimal toxicity. MRI with Mn-EOB-PC2A demonstrated strong liver-specific enhancement at a clinically relevant dose, underscoring the potential for Mn-EOB-PC2A as an alternative to traditional liver-targeted Gd-based platforms.

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