Modifications to the CF3 side-group of teriflunomide were made to improve its detection by 19F MRI. Pentafluorosulfanyl (SF5) was shown to be a superior alternative to CF3. The SNR efficiency of three 19F MRI methods showed that within a biological environment, SF5-substitutions gave the highest SNR efficiency in combination with an ultrashort echo-time (UTE) MRI method. Chemical modifications did not hamper biological activity but SF5-TF was more effective to inhibit T cell proliferation, indicating better anti-inflammatory activity. This study proposes SF5 as a novel superior 19F MR reporter group for the drug teriflunomide.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords