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Abstract #1994

HyperCEST Performance of Liposomal Nanocarriers using a CrA-Lipopeptide Building Block

Leif Schröder1 and Jan Oliver Jost1
1Translational Molecular Imaging, Deutsches Krebsforschungszentrum, Heidelberg, Germany


MRI reporters for hyperpolarized 129Xe CEST need further improvement in order to sufficiently outcompete the intrinsic loss of hyperpolarization appearing under in vivo conditions. This study opens up a possibility by accelerating the CEST build-up for the well-known Xe host CrA-ma by two orders of magnitude. We designed a liposome decorated with a CrA-lipopeptide. To avoid inefficiency from back exchange, the lipopeptide fraction should be kept relatively low (e.g., 2 mol%). Complete saturation transfer could be easily achieved for maximum possible image contrast in 129Xe MRI scans. This study pinpoints a large flexibility for designing powerful HyperCEST agents.

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