Abstract #1995

Detection of low-boiling point perfluorocarbon nanodroplets using hyperCEST: a path toward a dual-modality dual-phase contrast agent

Christian T McHugh^1,2, Phillip G Durham³, Michele Kelley^1,2, Nicholas J Bryden^1,2, Paul A Dayton^2,4, and Rosa T Branca^1,2

¹Physics & Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁴Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Synopsis

Recently, it was shown that hyperCEST enables detection of microbubbles at clinically relevant ultrasound doses. Nanodroplets filled with low-boiling point perfluorocarbons are precursors of microbubbles. Because the chemical shift of xenon in liquid-phase perfluorocarbon nanodroplets is different than that in gas-phase microbubbles, hyperCEST detection of these nanodroplets could enable MR detection of their phase-change upon ultrasound activation. To this end, here we investigate if perfluorocarbon nanodroplets can be used as hyperCEST agent, first in vitro and then in vivo.

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