Abstract #1996

GlucoCEST under the influence of head motion at 3 T: A numerical head phantom

Patrick Michael Lehmann¹, Mads Andersen^2,3, Anina Seidemo¹, Xiang Xu^4,5, Xu Li^5,6, Nirbhay Yadav^5,6, Ronnie Wirestam¹, Patrick Liebig⁷, Frederik Testud⁸, Pia Sundgren^3,9,10, Peter C. van Zijl^5,6, and Linda Knutsson^1,5,6

¹Department of Medical Radiation Physics, Lund University, Lund, Sweden, ²Philips Healthcare, Copenhagen, Denmark, ³Lund University Bioimaging Centre, Lund University, Lund, Sweden, ⁴BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁵Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁷Siemens Healthcare GmbH, Erlangen, Germany, ⁸Siemens Healthcare AB, Malmö, Sweden, ⁹Department of Radiology, Lund University, Lund, Sweden, ¹⁰Department of Medical Imaging and physiology, Skåne University hospital, Lund, Sweden

Synopsis

D-glucose is proposed as a cheap biodegradable alternative to gadolinium-based contrast agents. By performing glucoCEST imaging during and after administration of glucose, an approach referred to as dynamic glucose-enhanced (DGE) MRI, information about glucose delivery and uptake can be obtained. However, the small DGE signal changes at 3 T can easily be corrupted by motion. Furthermore, standard retrospective motion correction may erroneously alter true DGE signal, which may lead to misinterpretation. We designed a numerical head phantom that can be used for validation of motion correction and providing insight into the corresponding effects in vivo.

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