GlucoCEST under the influence of head motion at 3 T: A numerical head phantom
Patrick Michael Lehmann1, Mads Andersen2,3, Anina Seidemo1, Xiang Xu4,5, Xu Li5,6, Nirbhay Yadav5,6, Ronnie Wirestam1, Patrick Liebig7, Frederik Testud8, Pia Sundgren3,9,10, Peter C. van Zijl5,6, and Linda Knutsson1,5,6
1Department of Medical Radiation Physics, Lund University, Lund, Sweden, 2Philips Healthcare, Copenhagen, Denmark, 3Lund University Bioimaging Centre, Lund University, Lund, Sweden, 4BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 5Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 7Siemens Healthcare GmbH, Erlangen, Germany, 8Siemens Healthcare AB, Malmö, Sweden, 9Department of Radiology, Lund University, Lund, Sweden, 10Department of Medical Imaging and physiology, Skåne University hospital, Lund, Sweden
D-glucose is proposed as a cheap biodegradable alternative to gadolinium-based contrast agents. By performing glucoCEST imaging during and after administration of glucose, an approach referred to as dynamic glucose-enhanced (DGE) MRI, information about glucose delivery and uptake can be obtained. However, the small DGE signal changes at 3 T can easily be corrupted by motion. Furthermore, standard retrospective motion correction may erroneously alter true DGE signal, which may lead to misinterpretation. We designed a numerical head phantom that can be used for validation of motion correction and providing insight into the corresponding effects in vivo.
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