Numerical optimization and validation of Lactate CEST (LATEST) imaging at 3T: In-situ and in-vivo feasibility studies
Karl Ludger Radke1, Daniel Benjamin Abrar1, Miriam Frenken1, Lena Marie Wilms1, Matthias Boschheidgen1, Patrick Liebig2,3, Alexandra Ljimani1, Sven Nebelung1,4, Hans-Jörg Wittsack1, and Anja Müller-Lutz1
1University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Düsseldorf, Germany, 2Cent. of Med. Phys. and Biomed. Eng., Friedrich-Alexander-Univ. Erlangen-Nürnberg, Erlangen, Germany, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Department of Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany
Quantification of altered lactate concentrations with non-invasive MR imaging is of diagnostic interest in a broad spectrum of diseases and further analysis of athletic activity. In this context, chemical exchange saturation transfer (CEST) is an increasingly validated contrast mechanism in MRI. However, successful application of CEST requires efficient selective saturation of the exchanging lactate protons. In this study, we successfully optimized and investigated the application of intramuscular lactate CEST imaging (LATEST) supported by numerical simulations and were able to apply LATEST for the first time in-vivo at 3.0 T.
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