Quantification of altered lactate concentrations with non-invasive MR imaging is of diagnostic interest in a broad spectrum of diseases and further analysis of athletic activity. In this context, chemical exchange saturation transfer (CEST) is an increasingly validated contrast mechanism in MRI. However, successful application of CEST requires efficient selective saturation of the exchanging lactate protons. In this study, we successfully optimized and investigated the application of intramuscular lactate CEST imaging (LATEST) supported by numerical simulations and were able to apply LATEST for the first time in-vivo at 3.0 T.
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