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Abstract #1998

Simultaneous molecular 68Ga-PRDG2 and perfusion PET-MR imaging in a patient with sickle cell disease

Chan Hong Moon1, Carolyn Anderson1,2,3,4,5, Sina Tavakoli 5,6, Tiffany Pham 6, Lydia Perkins5, Lynda Little-Ihrig5, Neal Mason1, Xiaoyuan Chen7, Charles Laymon1,2, Mark Gladwin5, and Enrico Novelli 3,5
1Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, 3Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States, 4Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, United States, 5Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States, 6Gilead Sciences, Foster City, CA, United States, 7National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, United States

Synopsis

Sickle cell disease (SCD) causes vaso-occlusion, ischemia, and end-organ infarction that causes acute pain episodes, also known as vaso-occlusive crises (VOC). Understanding the mechanism underlying VOC is critical to identify patients at risk and for accurate diagnosis while in VOC. PET imaging with the probe 68Ga-PRGD2 that binds integrin αvβ3 identified areas of increased binding of sickle RBC to the endothelium in VOC. Simultaneous PET-MR imaging could provide additional information on tissue changes associated with VOC. Thus, we imaged a patient with SCD with 68Ga-PRGD2 in combination with MRI by using PET-MR 3T scanner.

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Abstract

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