In this study, we investigated the optimal acquisition parameters in terms of voxel size, SNR and total scan time to obtain high quality NAD+ 1H downfield (>4.7 ppm) spectra from human brain at 7 Tesla. Using a spectrally selective excitation spatially selective localization pulse sequence and without water suppression, large voxel size and shorter TR, we were able to acquire NAD+ spectra with an SNR of ~30 in about 5 min. Preliminary results of high SNR and resolution enhanced NAD+ spectra from human brain of healthy volunteers are presented.
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