Abstract #2014

Fast scan downfield MR spectra of human brain in vivo at 7.0 Tesla

Ravi Prakash Reddy Nanga¹, Mark Elliott², Neil Wilson², Sophia Swago³, Walter Witschey², and Ravinder Reddy²

¹Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States, ²Radiology, Center for Advance Metabolic Imaging in Precision Medicine, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States, ³Bioengineering, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

In this study, we investigated the optimal acquisition parameters in terms of voxel size, SNR and total scan time to obtain high quality NAD⁺ ¹H downfield (>4.7 ppm) spectra from human brain at 7 Tesla. Using a spectrally selective excitation spatially selective localization pulse sequence and without water suppression, large voxel size and shorter TR, we were able to acquire NAD⁺ spectra with an SNR of ~30 in about 5 min. Preliminary results of high SNR and resolution enhanced NAD⁺ spectra from human brain of healthy volunteers are presented.

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