A concurrent tDCS-MEGA PRESS MRS study to investigate polarity dependent effects on neurometabolites
Rajakumar Nagarajan1, Anant Shinde2,3, Muhammed Enes Gunduz4, and Gottfried Schlaug1,2,3
1Human Magnetic Resonance Center, Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, United States, 2Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, United States, 3University of Massachusetts Medical School - Baystate Medical Center, Springfield, MA, United States, 4University of Massachusetts Medical School, Worcester, MA, United States
Up- or downregulation of neurotransmitter/receptor concentration have been seen when transcranial direct current stimulation (tDCS) and proton Magnetic Resonance Spectroscopy (MRS) were combined in concurrent experiments; however, results have been mixed and not reliable across studies. In this study, we investigated dose and polarity effects of tDCS in an MRS voxel centered over the anterior cingulate/prefrontal region using three dose levels of tDCS with stimulation electrode placed over left a supraorbital area and return electrode over right mastoid bone. Dose and polarity dependent modulation of GABA and Glx was observed in a single subject study.
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