Abstract #2015

A concurrent tDCS-MEGA PRESS MRS study to investigate polarity dependent effects on neurometabolites

Rajakumar Nagarajan¹, Anant Shinde^2,3, Muhammed Enes Gunduz⁴, and Gottfried Schlaug^1,2,3

¹Human Magnetic Resonance Center, Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, United States, ²Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, United States, ³University of Massachusetts Medical School - Baystate Medical Center, Springfield, MA, United States, ⁴University of Massachusetts Medical School, Worcester, MA, United States

Synopsis

Up- or downregulation of neurotransmitter/receptor concentration have been seen when transcranial direct current stimulation (tDCS) and proton Magnetic Resonance Spectroscopy (MRS) were combined in concurrent experiments; however, results have been mixed and not reliable across studies. In this study, we investigated dose and polarity effects of tDCS in an MRS voxel centered over the anterior cingulate/prefrontal region using three dose levels of tDCS with stimulation electrode placed over left a supraorbital area and return electrode over right mastoid bone. Dose and polarity dependent modulation of GABA and Glx was observed in a single subject study.

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